Madonna has been discharged from hospital and is home and feeling better after an intensive care stay, the BBC understands.
News of her ill health was shared by her manager, who said she had suffered a "serious bacterial infection".
The 64-year-old was due to begin a seven-month world tour in the coming weeks, but has had to postpone it.
She was taken to her New York home in a private ambulance, a source told CNN, adding: "She's in the clear."
It is not known what initially caused Madonna's infection, but doctors said it became extremely serious and required treatment in intensive care.
Infections can develop into a life-threatening condition called sepsis or blood poisoning.
Madonna, who is very private about health matters, was in the final stages of rehearsals ahead of her extensive world tour.
The Celebration tour was due to begin in Canada in two weeks' time, before visiting 45 cities across the world.
It was due to be her 12th tour, marking 40 years of involvement in the music industry.
Details of whether the tour will still go ahead are yet to be announced.
The singer has received thousands of messages of support online since a statement on her health was made by manager Guy Oseary.
Well wishes have come from The Weeknd, real name Abel Tesfaye, who said he was "sending prayers" and from Desperately Seeking Susan co-star Rosanna Arquette, who wrote that she was sending "love and good light vibrations" for recovery.
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